Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing

The acute wound healing process requires a quick and short-stage vascular endothelial growth factor (VEGF) supply, especially, in the early-stage of injury. To date, research has rarely met demand for controlled VEGF release. Herein, novel wheel spinning technique was introduced to fabricate alginate (Alg)/silk fibroin (SF) composite fiber loading achieving controllable In turn, it demonstrated that parameter Alg/SF material morphological combination significantly influence release behavior degradation speed, which could be by adjusting solution concentration modifying SF morphology. structural features interacted with each other affect behavior, indicating factors such as released fashion. It therefore developed approach control process.